What is Absorption of Drug

ABSORPTION OF DRUG

Once the drug is administered in the body, it undergoes a chain of complex events till it reaches to its site of action, which is represented in the following

The process by which the drug is released in the body from its dosage form is known as absorption. The factors which affect the rate of absorptions are:

1. Concentration of the drug
2. Route of administration
3. Solubility of the drug
4. Dissolution rate for solid dosage form
5. Blood circulation to the site of application and the area of the absorbing surface in local applications
6. Physiochemical parameters of the drug

To reach the site of action, the drugs has to cross one or more membrane

barriers. The main process by which a drug molecule crosses the natural barrier is.

(i) Simple diffusion

(iii) Facilitated diffusion

(v) Pore transport

(ii) Diffusion of ions across the membrane

(iv) Active transport

(vi) Phagocytosis.

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