Micromeritics
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CONTAINTS
- Particles-Characteristics
- Powder-Characteristics
- Powder-Particle Size Distribution
- Powder-Distribution Curve Analysis of Data
- Particle Size Determination-Methods
- Powder Surface Area- Method
- Derived Properties of Powders
What is Micromeritics
Micromeritics involve the study of small particles and of the order of a few microns size. This study involves the characterisation of india virtual particles, particle size distribution and powders. Further, their relevance as pharmaceutical attributes and biological necessities are important to the pharmacist, owing to their use in the manufacture of dosage forms. Particles are characterised by the following properties.
- Size
- Shape
- Volume surface area
- Density porosity
- Flow
- Associated properties
Particle size is normally denoted in micrometers (formerly called as microns, ) um One micrometer is equal to 10mm (millimeters) or 10 m. The term 'millimicrometer" is presently called nanometer (mm) and equal to 10 meters or 10 millimeter or 10 m (micrometer) Knowledge and control of these properties is important in pharmacy.
The application of micromeritics in pharmacy are as follows:
Release and Dissolution of Micromeritics :
Particle size and surface area influence the release of drug from a dosage form that is administered orally, rectally, parenterally and topically. Higher surface area brings about intimate contact of the drug with the dissolution fluids in vivo and increases the drug solubility and dissolution. In general, higher the surface area, better the release. Hence faster is the dissolution.
Absorption and drug action of Micromeritics :
Particle size and surface area influ ence the drug absorption and subsequently the therapeutic action. Higher the dissolution, faster the absorption. Hence, quicker and greater is the drug action.
Physical stability in Micromeritics :
Particle size influences the physical stability of suspensions and emulsions. Smaller the size of particles, better the physical stability of the dosage form owing to Brownian movement of the particles in the dispersion.
Dose uniformity in Micromeritics :
Good flow properties of granules and powders are important in the manufacture of tablets and capsules. The distribution of particles should be uniform in terms of its number and weight. At the same time, the flow of granules should be uniform in order to ensure precise weight of the tablet and drug content.
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